SML0374

U-104

≥98% (HPLC)

• 同義詞: 4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzenesulfonamide, NSC 213841
• 經驗公式（希爾表示法）: C₁₃H₁₂FN₃O₃S
• CAS號碼: 178606-66-1
• 分子量：: 309.32
• MDL號碼: MFCD00159265
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825375
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: >15 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(NC1=CC=C(S(N)(=O)=O)C=C1)NC2=CC=C(F)C=C2
• InChI: 1S/C13H12FN3O3S/c14-9-1-3-10(4-2-9)16-13(18)17-11-5-7-12(8-6-11)21(15,19)20/h1-8H,(H2,15,19,20)(H2,16,17,18)
• InChI 密鑰: YJQZNWPYLCNRLP-UHFFFAOYSA-N

描述

生化／生理作用

U-104 is an inhibitor of CA IX that binds only to CA IX under hypoxic conditions in vivo. The binding results in significant inhibition of tumor growth and metastasis formation in both spontaneous and experimental models of metastasis. U-104 reduces the medium acidity by inhibiting the catalytic activity of the CA IX. It binds specifically only to hypoxic cells expressing CA IX.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable