SML0372

NSC23925

≥98% (HPLC)

• 同義詞: 2-(p-Methoxyphenyl)-α-2-piperidyl-4-quinolinemethanol dihydrochloride, NSC-23925, [2-(4-Methoxyphenyl)4-quinolinyl]-(piperidin-2-y)-methanol dihydrochloride
• 經驗公式（希爾表示法）: C₂₂H₂₄N₂O₂ · 2HCl
• CAS號碼: 858474-14-3
• 分子量：: 421.36
• MDL號碼: MFCD22666390
• 分類程式碼代碼: 12161501
• PubChem物質ID: 329825373
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white to beige
• 溶解度: H₂O: 5 mg/mL (clear solution)
• 儲存溫度: room temp
• SMILES 字串: Cl.Cl.COc1ccc(cc1)-c2cc(C(O)C3CCCCN3)c4ccccc4n2
• InChI: 1S/C22H24N2O2.2ClH/c1-26-16-11-9-15(10-12-16)21-14-18(17-6-2-3-7-19(17)24-21)22(25)20-8-4-5-13-23-20;;/h2-3,6-7,9-12,14,20,22-23,25H,4-5,8,13H2,1H3;2*1H
• InChI 密鑰: WGWOQHWZXLGPNG-UHFFFAOYSA-N

描述

生化／生理作用

NSC23925 is a specific Pgp1 inhibitor. It reverses MDR1 (Pgp1) but does not inhibit MRP or BCRP-mediated MDR. NSC23925 itself is not a substrate of Pgp1 but stimulates ATPase activity of Pgp, directly inhibiting the function of Pgp1 in a dose-dependent manner without altering the total expression level of Pgp1.

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301
• 防範說明: P264 - P270 - P301 + P310 - P405 - P501
• 危險分類: Acute Tox. 3 Oral
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable