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SML0334

Sigma-Aldrich

DMPQ dihydrochloride

≥98% (HPLC)

同義詞:

5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride

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About This Item

經驗公式(希爾表示法):
C16H14N2O2 · 2HCl
CAS號碼:
分子量::
339.22
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

H2O: >10 mg/mL

儲存溫度

room temp

SMILES 字串

Cl.Cl.COc1cc(OC)c2cc(cnc2c1)-c3ccncc3

InChI

1S/C16H14N2O2.2ClH/c1-19-13-8-15-14(16(9-13)20-2)7-12(10-18-15)11-3-5-17-6-4-11;;/h3-10H,1-2H3;2*1H

InChI 密鑰

YBBAOKYVJCNJIV-UHFFFAOYSA-N

生化/生理作用

DMPQ is a potent selective inhibitor of human vascular beta-type platelet derived growth factor receptor tyrosine kinase (PDGFR?) with IC50 = 80 nM. It is > 100-fold selective over EGFR, erbB2, p56, protein kinase A and protein kinase C.

特點和優勢

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the PDGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Wafa Altalhi et al.
Biomaterials, 119, 23-32 (2016-12-19)
Cell-based tissue engineering is a potential treatment alternative for organ replacement. However, the lack of a robust vasculature, especially in the context of diseases such as diabetes, is a major hindrance to its success. Despite extensive research on the effects
Akshaya Srinivasan et al.
Biomaterials, 167, 153-167 (2018-03-24)
Mesenchymal stem cells (MSCs) have been isolated from various mesodermal and ectodermal tissues. While the phenotypic and functional heterogeneity of MSCs stemming from their developmental origins has been acknowledged, the genetic and environmental factors underpinning these differences are not well-understood.

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