SML0152

AK-7

≥98% (HPLC)

• 經驗公式（希爾表示法）: C₁₉H₂₁BrN₂O₃S
• CAS號碼: 420831-40-9
• 分子量：: 437.35
• MDL號碼: MFCD03140195
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825200
• NACRES: NA.25

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to tan
• 溶解度: DMSO: ≥15 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: Brc1cccc(NC(=O)c2cccc(c2)S(=O)(=O)N3CCCCCC3)c1
• InChI: 1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23)
• InChI 密鑰: IYAYHZZWYNXHEQ-UHFFFAOYSA-N

描述

一般說明

AK-7 (3-(1-azepanylsulfonyl)-N-(3-bromphenyl) benzamide) is a cell- and brain-permeable, selective SIRT2 (sirtuin 2) inhibitor.

應用

AK-7 has been used in cell culture and cell treatment.

生化／生理作用

AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.

In neurons, the sirtuin 2 inhibitor AK-7 is neuroprotective in vitro and decreases polyglutamine inclusions and cholesterol levels. In mice, treatment with brain-permeable SIRT2 inhibitor AK-7 led to improved motor function, extended survival and decreased brain atrophy. AK-7 decreases the polyglutamine aggregation in R6/2 brain.

Selective SIRT2 Inhibitor

Selective SIRT2 Inhibitor AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H319
• 防範說明: P264 - P280 - P305 + P351 + P338 - P337 + P313
• 危險分類: Eye Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable