SML0128

M30 dihydrochloride

≥98% (HPLC)

• 同義詞: 5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride, M-30 dihydrochloride, VAR10300 dihydrochloride
• 經驗公式（希爾表示法）: C₁₄H₁₄N₂O · 2HCl
• CAS號碼: 64821-19-8
• 分子量：: 299.20
• MDL號碼: MFCD20488063
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825178
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: green-yellow
• 溶解度: DMSO, heptane and xylene: ≥21 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: Cl.Cl.CN(CC#C)Cc1ccc(O)c2ncccc12
• InChI: 1S/C14H14N2O.2ClH/c1-3-9-16(2)10-11-6-7-13(17)14-12(11)5-4-8-15-14;;/h1,4-8,17H,9-10H2,2H3;2*1H
• InChI 密鑰: XJNICPXVRPOSSO-UHFFFAOYSA-N

描述

應用

M30 dihydrochloride may be used in monamine oxidase-mediated cell signaling studies.

生化／生理作用

M30 is a site-activated iron chelator and monoamine oxidase (MAO) inhibitor; with neuroprotective and anti-apoptotic activity. It is a multifunctional non-toxic, brain permeable iron chelator possessing a neuroprotective propargylamine moiety and an antioxidant-iron chelator moiety. M30 is a selective irreversible inhibitor of mitochondrial brain monoamine oxidases A and B (MAO-A and -B), providing for improved levels of neurotransmitters. It reduces oxidative damage and shows neuroprotective and neurorestorative effects in various neurodegenerative models of ALS, Alzheimer′s and Parkinson′s diseases, and is being investigated in other diseases where oxidative stress is a problem.

Site-activated iron chelator and monoamine oxidase (MAO) inhibitor; neuroprotective and anti-apoptotic

特點和優勢

This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全資訊

• 象形圖: GHS05,GHS07
• 訊號詞: Danger
• 危險聲明: H302,H318
• 防範說明: P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
• 危險分類: Acute Tox. 4 Oral - Eye Dam. 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable