SMB01078

Inulicin

≥90% (LC/MS-ELSD)

• 同義詞: 1-O-Acetylbritannilactone, Britannilactone 1-O-acetate
• 經驗公式（希爾表示法）: C₁₇H₂₄O₅
• CAS號碼: 33627-41-7
• 分子量：: 308.37
• MDL號碼: MFCD30207877
• 分類程式碼代碼: 12352205
• NACRES: NA.25

屬性

• 生物源: plant
• 化驗: ≥90% (LC/MS-ELSD)
• 形狀: solid
• 分子量: 308.37
• 應用: metabolomics; vitamins, nutraceuticals, and natural products
• 儲存溫度: −20°C
• InChI: 1S/C17H24O5/c1-9(6-5-7-21-12(4)18)14-10(2)8-13-15(16(14)19)11(3)17(20)22-13/h9,13,15-16,19H,3,5-8H2,1-2,4H3/t9-,13+,15+,16+/m0/s1
• InChI 密鑰: QKUFZFLZBUSEHN-CZLJMHDISA-N

描述

一般說明

Inulicin, a sesquiterpene lactone, is a natural bioactive compound commonly sourced from plants like Pentanema britannicum and Inula japonica. Current research indicates that this plant-derived metabolite may possess inhibitory properties, showcasing a range of biological activities, including anti-inflammatory, cardioprotective, antiangiogenic, and anticancer activities.

應用

Inulicin is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

生化／生理作用

Inulicin exhibits anticancer properties by inhibiting angiogenesis and lung cancer cell proliferation, potentially through the regulation of VEGFR-Src-FAK signaling. When combined with gemcitabine, it promotes strong apoptosis in lung cancer cells. Additionally, Inulicin shows promise in the treatment of various cardiovascular diseases, including chronic ischemia, by modulating VEGF signaling and angiogenesis. It also serves as a potent inhibitor of LPS-induced inflammatory responses in vascular smooth muscle cells, acting through the blockade of NF-kappaB activity and the suppression of the inflammatory gene COX-2. Furthermore, Inulicin displays potential as a natural skin-lightening agent, reducing melanogenesis by suppressing tyrosinase expression via ERK and Akt signaling pathways.

特點和優勢

• Suitable for Biochemical and Biomedical research
• Versatile and adaptable for wide variety of laboratory and research applications

其他說明

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安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable