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Key Documents

SMB01077

Sigma-Aldrich

Poliothyrsoside

≥85% (LC/MS-ELSD)

同義詞:

Nigracin

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About This Item

經驗公式(希爾表示法):
C20H22O9
CAS號碼:
分子量::
406.38
MDL號碼:
分類程式碼代碼:
12352205
NACRES:
NA.25

生物源

plant

化驗

≥85% (LC/MS-ELSD)

形狀

solid

分子量

406.38

應用

metabolomics
vitamins, nutraceuticals, and natural products

儲存溫度

−20°C

InChI

1S/C20H22O9/c21-9-12-8-13(22)6-7-14(12)28-20-18(25)17(24)16(23)15(29-20)10-27-19(26)11-4-2-1-3-5-11/h1-8,15-18,20-25H,9-10H2/t15-,16-,17+,18-,20-/m1/s1

InChI 密鑰

FLROYCKIIJCTDY-BFMVXSJESA-N

一般說明

Poliothyrsoside, also known as Nigracin, is a phenolic glycoside compound commonly found in plants such as Flacourtia indica, Loxocalyx urticifolius, Hydnocarpus annamensis, Xylosma flexuosa, Poliothyrsis sinensis, and Scolopia spinosa. Existing research suggests that this plant-derived metabolite exerts various biological activities, antioxidant, antidiabetic, anti-alzheimers and antiplasmodial properties.

應用

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical and biochemical research.

生化/生理作用

Poliothyrsoside is a pyruvic transaminase inhibitor known for its insulin-sensitizing effects in cell culture. Additionally, it exhibits anti-diabetic properties by inhibiting acetyl-CoA carboxylase, ultimately enhancing insulin sensitivity and lowering blood glucose levels in diabetic mice. This compound also serves as a lactate dehydrogenase inhibitor and demonstrates antidepressant-like actions, along with effectiveness against Alzheimer′s disease. In vitro studies have further revealed Poliothyrsoside′s capacity to inhibit virus production and exhibit antiviral activity against HIV-1.

特點和優勢

  • High quality compound suitable for multiple research applications
  • Compatible with HPLC and mass spectrometry techniques

其他說明

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儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Gianluca Sferrazza et al.
Frontiers in pharmacology, 10, 1541-1541 (2020-02-11)
Drypetes klainei Pierre ex Pax is used in Cameroon by Baka people in the wound healing process and for the treatment of burns. In a previous paper we demonstrated the ability of both water (WE) and defatted methanol (DME) extracts

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