SMB01000

Grandiflorenic acid

≥90% (LC/MS-ELSD)

• 同義詞: (4S,5R,9R)-5,9-Dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadec-10-ene-5-carboxylic acid, Kaura-9(11),16-dien-18-oic acid
• 經驗公式（希爾表示法）: C₂₀H₂₈O₂
• CAS號碼: 22338-67-6
• 分子量：: 300.44
• MDL號碼: MFCD23103740
• 分類程式碼代碼: 12352205
• NACRES: NA.25

屬性

• 生物源: plant
• 化驗: ≥90% (LC/MS-ELSD)
• 形狀: solid
• 分子量: 300.44
• 溶解度: water: slightly soluble
• 應用: metabolomics; vitamins, nutraceuticals, and natural products
• 儲存溫度: −20°C
• SMILES 字串: OC(=O)[C@]1([C@@H]2[C@@](CCC1)(C3=CCC4CC3(CC2)CC4=C)C)C
• InChI: 1S/C20H28O2/c1-13-11-20-10-7-15-18(2,16(20)6-5-14(13)12-20)8-4-9-19(15,3)17(21)22/h6,14-15H,1,4-5,7-12H2,2-3H3,(H,21,22)/t14?,15-,18+,19+,20?/m0/s1
• InChI 密鑰: RJIPNPHMQGDUBW-MZWQVCBVSA-N

描述

一般說明

Grandiflorenic acid, a diterpenoid, is a natural product commonly derived from Wedelia trilobata, Sphagneticola trilobata and Siegesbeckia orientalis L. It exhibits various biological activities such as anti-inflammatory, anti-depressant, anti-fertility, and anti-microbial properties.

應用

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

生化／生理作用

Grandiflorenic acid exhibits antibacterial, anti-inflammatory, antileishmanial and wound-healing properties.
Grandiflorenic acid shows moderate cytotoxic (IC50 15μM in RAW264.7 cells) and antiplasmodial activities (IC50 23μM against P. falciparum).

Grandiflorenic acid (GFA) shows promise as an anticancer agent by inhibiting cell proliferation and reducing cell size in breast (MCF7), lung (A549), and liver (HuH7.5) tumor cell lines. Further, it also shows effects on uterine motility throughout the estrus cycle suggesting it may have antifertility properties, possibly by affecting hormones and adrenergic pathways in the uterus.

特點和優勢

• High quality compound suitable for multiple research applications
• Compatible with HPLC and mass spectrometry techniques

其他說明

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安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable