推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to off-white
mp
222 °C ((432 °F ))
溶解度
water: soluble
儲存溫度
2-8°C
InChI
1S/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1
InChI 密鑰
PTJWIQPHWPFNBW-GBNDHIKLSA-N
一般說明
伪尿苷是一种C-糖基嘧啶，由尿嘧啶组成，尿嘧啶在位置5处连接有β-D-呋喃呋喃糖基残基。嘧啶核苷尿苷的C-糖基异构体。它具有基本代谢物的作用。假尿苷存在于除mRNA以外的所有物种和所有类别的RNA中。它由称为假尿苷合酶的酶形成，该酶在转录后异构化RNA中的特定尿苷残基。
假尿嘧啶(Ψ)是核苷尿嘧啶的同分异构体，具有碳-碳键而不是典型的连接尿嘧啶的氮-碳糖苷键。它代表了RNA内无数修饰核苷中最普遍的形态，存在于各种物种和RNA类别中。Ψ合成酶的酶促作用诱导特定尿嘧啶残基的转录后异构化，这一过程被称为假尿嘧啶化。这种修饰，特别是在rRNA和tRNA中，在微调和稳定区域结构中起着至关重要的作用，有助于mRNA解码、核糖体组装、加工和转译功能。此外，在细菌、古细菌和真核生物的tRNA中发现的β-假尿嘧啶已被证明具有减少人类淋巴细胞中辐射诱导的染色体畸变的潜力。它作为癌症和增殖生物标志物的效用使其成为代谢组学和生化研究的宝贵资产。
應用
伪尿嘧啶是一种用途广泛的化合物和生物标志物，可用于代谢组学和生化研究。
特點和優勢
- 高纯度化合物适用于各种研究应用
其他說明
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儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Mohammad Ariful Islam et al.
Biomaterials, 266, 120431-120431 (2020-10-26)
Synthetic mRNA represents an exciting cancer vaccine technology for the implementation of effective cancer immunotherapy. However, inefficient in vivo mRNA delivery along with a requirement for immune co-stimulation present major hurdles to achieving anti-tumor therapeutic efficacy. Here, we demonstrate a
Ryota Kurimoto et al.
The EMBO journal, 39(20), e104708-e104708 (2020-09-15)
Let-7 is an evolutionary conserved microRNA that mediates post-transcriptional gene silencing to regulate a wide range of biological processes, including development, differentiation, and tumor suppression. Let-7 biogenesis is tightly regulated by several RNA-binding proteins, including Lin28A/B, which represses let-7 maturation.
Matthias Heiss et al.
Nature communications, 12(1), 389-389 (2021-01-17)
Recently, studies about RNA modification dynamics in human RNAs are among the most controversially discussed. As a main reason, we identified the unavailability of a technique which allows the investigation of the temporal processing of RNA transcripts. Here, we present
Tingting Jiang et al.
Nature communications, 11(1), 1979-1979 (2020-04-26)
CRISPR-Cas9-associated base editing is a promising tool to correct pathogenic single nucleotide mutations in research or therapeutic settings. Efficient base editing requires cellular exposure to levels of base editors that can be difficult to attain in hard-to-transfect cells or in
Tatsuro Hagi et al.
Applied microbiology and biotechnology, 104(24), 10641-10653 (2020-11-08)
Akkermansia muciniphila is a prominent member of the gut microbiota and the organism gets exposed to bile acids within this niche. Several gut bacteria have bile response genes to metabolize bile acids or an ability to change their membrane structure
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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