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Key Documents

SCP0247

Sigma-Aldrich

因子VIIa底物

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About This Item

經驗公式(希爾表示法):
C30H42N7O7S1
分子量::
644.76
分類程式碼代碼:
12352200
NACRES:
NA.32

化驗

≥95% (HPLC)

形狀

lyophilized

成份

Peptide Content, ≥72%

儲存條件

protect from light

儲存溫度

−20°C

Amino Acid Sequence

MeSO2-Cha-Abu-Arg-AFC

應用

因子VIIa是一种参与血液凝固级联反应的丝氨酸蛋白酶。可以用生色底物MeSO2-Cha-Abu-Arg-pNA或生色底物Meso2-Cha-Abu-Arg-AFC测定因子VIIa的活性。

分析證明 (COA)

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Giuseppe Lippi et al.
Seminars in thrombosis and hemostasis, 35(1), 9-22 (2009-03-25)
Hemostasis is traditionally defined as the physiologic process whereby bleeding is antagonized and possibly stopped to minimize blood loss. The first medical description of the clinical and inherited features of hemostasis can be dated back more than 1000 years, when
Flora Peyvandi et al.
Thrombosis and haemostasis, 88(5), 750-755 (2002-11-13)
Factor VII (FVII) requires the cleavage of an internal peptide bond and the association with tissue factor (TF) to attain its fully active FVIIa conformation. This event alone leaves FVIIa in a zymogen-like state of relatively low specific activity. The

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