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Merck
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Key Documents

SCP0196

Sigma-Aldrich

Myosin Light Chain Kinase Substrate

≥95% (HPLC), lyophilized

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About This Item

經驗公式（希爾表示法）:
C61H107N23O16
分子量：:
1418.65
分類程式碼代碼:
12352202
NACRES:
NA.32

product name

Myosin Light Chain Kinase Substrate (smooth muscle),

化驗

≥95% (HPLC)

形狀

lyophilized

成份

Peptide Content, ≥62%

儲存條件

protect from light

儲存溫度

−20°C

Amino Acid Sequence

Lys-Lys-Arg-Ala-Ala-Arg-Ala-Thr-Ser-Asn-Val-Phe-Ala-NH2

一般說明

Myosin light chain kinase (MLCK) comprises an N-terminal actin-binding domain, a central kinase domain, and a C-terminal myosin-binding domain.

應用

Myosin Light Chain Kinase Substrate (smooth muscle) has been used in MLCK activity assay to study the role of Plasmodium falciparum calmodulin (Pf CaM).

生化／生理作用

KKRAARATSNVFA-NH2 is used as a myosin light chain kinase (MLCK) substrate.
Myosin light chain kinase (MLCK) is involved in modulating the actin-myosin interaction of smooth muscle. In addition to its kinase activity, MLCK also has actin-binding activity, which can assemble actin filaments into bundles. It also has myosin-binding activity, which can generate myosin filaments.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

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Yevgeny Zolotarevsky et al.
Gastroenterology, 123(1), 163-172 (2002-07-10)
Maintenance of the mucosal barrier is a critical function of intestinal epithelia. Myosin regulatory light chain (MLC) phosphorylation is a common intermediate in the pathophysiologic regulation of this barrier. The aim of this study was to determine whether a membrane
A V Marchenko et al.
Biofizika, 55(6), 1008-1013 (2011-01-28)
The ability of novel cell-permeating peptide molecules derived from the peptide inhibitor of the myosin light chain kinase (MLCK) L-PIK (Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys) to inhibit this kinase in vitro and attenuate the thrombin-induced hyperpermeability of endothelial cell monolayer in culture has been
Haruhiko Ohtsu et al.
Arteriosclerosis, thrombosis, and vascular biology, 25(9), 1831-1836 (2005-07-05)
Rho and its effector Rho-kinase/ROCK mediate cytoskeletal reorganization as well as smooth muscle contraction. Recent studies indicate that Rho and ROCK are critically involved in vascular remodeling. Here, we tested the hypothesis that Rho/ROCK are critically involved in angiotensin II
A V Sekridova et al.
Bioorganicheskaia khimiia, 36(4), 498-504 (2010-09-09)
Myosin light chain kinase (MLCK) is the key regulator of various forms of cell motility including endothelial and epithelial permeability in particular. One of the potential MLCK inhibitors to be used in humans is a membrane permeable peptide H-RKKYKYRRK-NH2 (L-PIK).

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