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Key Documents

SCP0011

Sigma-Aldrich

Akt Substrate

≥95% (HPLC), lyophilized

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About This Item

經驗公式(希爾表示法):
C36H60N14O8
分子量::
816.95
分類程式碼代碼:
12352200
NACRES:
NA.32

product name

Akt Substrate,

化驗

≥95% (HPLC)

形狀

lyophilized

成份

Peptide Content, ≥65%

儲存條件

protect from light

儲存溫度

−20°C

Amino Acid Sequence

Arg-Pro-Arg-Ala-Ala-Thr-Phe-NH2

應用

AKT refers to the serine/threonine protein kinases, AKT-1, AKT-2 and AKT-3, which are involved in the cellular processes of glucose metabolism, cell proliferation, apoptosis, transcription and cell migration. The peptide Arg-Pro-Arg-Ala-Ala-Thr-Phe may be a relatively specific substrate for PKBα (AKT-1) because, unlike other substrates, it is not phosphorylated by p70 S6 kinase or MAP kinase activated protein (MAPKAP) kinase-1.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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John N Hutchinson et al.
Cancer research, 64(9), 3171-3178 (2004-05-06)
Elevated expression of Akt-1 (PKBalpha) has been noted in a significant percentage of primary human breast cancers. Another frequent event in the genesis of human breast cancers is amplification and overexpression of the ErbB-2 receptor tyrosine kinase, an event which
D R Alessi et al.
FEBS letters, 399(3), 333-338 (1996-12-16)
The substrate specificity of protein kinase-B alpha (PKBalpha, also known as RAC kinase or Akt) was investigated using synthetic peptide substrates related to the sequence surrounding the phosphorylation site on glycogen synthase kinase-3 (GSK3). The minimum sequence motif required for
G Rena et al.
The Journal of biological chemistry, 274(24), 17179-17183 (1999-06-08)
Protein kinase B lies "downstream" of phosphatidylinositide (PtdIns) 3-kinase and is thought to mediate many of the intracellular actions of insulin and other growth factors. Here we show that FKHR, a human homologue of the DAF16 transcription factor in Caenorhabditis

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