SBR00038

Hygromycin B

Min. 95% (HPLC ELSD), from Streptomyces hygroscopicus

• 經驗公式（希爾表示法）: C₂₀H₃₇N₃O₁₃
• CAS號碼: 31282-04-9
• 分子量：: 527.52
• 分類程式碼代碼: 51281624
• NACRES: NA.76

屬性

• 產品名稱: Hygromycin B, Min. 95% (HPLC ELSD), from Streptomyces hygroscopicus
• 生物源: Streptomyces hygroscopicus
• 品質等級: 200
• 形狀: solid
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria; fungi; viruses
• 作用方式: protein synthesis | interferes
• 儲存溫度: 2-8°C
• SMILES 字串: N([C@@H]1[C@H]([C@@H]([C@H]([C@@H](C1)N)O)O[C@@H]2O[C@@H]([C@@H]([C@@H]3O[C@@]4(O[C@@H]32)O[C@@H]([C@@H]([C@@H]([C@H]4O)O)O)[C@H](N)CO)O)CO)O)C
• InChI: 1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1
• InChI 密鑰: GRRNUXAQVGOGFE-XKIAHZFYSA-N

描述

一般說明

Chemical structure: aminoglycoside

應用

Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It has been used to study protein synthesis at the level of the 70S ribosome translocation and mRNA template misreading, as an antiviral agent by selectively penetrating cells rendered permeable by virus infection and inhibiting translation, and as a selection agent for hygromycin resistance gene transformed cells. It is recommended for use as a selection agent at 100-800 μg/mL, specifically at 100 μg/mL for prokaryotes, 200 μg/mL for lower eukaryotes and 150-400 μg/mL for higher eukaryotes.

生化／生理作用

Mode of Action: The product acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation.

Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells.

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H300 + H310 + H330
• 防範說明: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• 危險分類: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable