SBR00037

Solithromycin

≥98% (HPLC)

• 同義詞: 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, CEM-101, OP-1068
• 經驗公式（希爾表示法）: C₄₃H₆₅FN₆O₁₀
• 分子量：: 845.01
• MDL號碼: MFCD30207880
• 分類程式碼代碼: 51102829
• NACRES: NA.76

屬性

• 品質等級: 200
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to off-white
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria
• 作用方式: protein synthesis | interferes
• 儲存溫度: −20°C
• InChI: 1S/C43H65FN6O10/c1-12-32-43(8)35(50(40(55)60-43)19-14-13-18-49-23-30(46-47-49)28-16-15-17-29(45)21-28)26(4)33(51)24(2)22-41(6,56-11)37(27(5)36(53)42(7,44)39(54)58-32)59-38-34(52)31(48(9)10)20-25(3)57-38/h15-17,21,23-27,31-32,34-35,37-38,52H,12-14,18-20,22,45H2,1-11H3/t24-,25-,26+,27+,31+,32-,34-,35-,37-,38+,41-,42+,43-/m1/s1
• InChI 密鑰: IXXFZUPTQVDPPK-ZAWHAJPISA-N

描述

一般說明

Solithromycin is a highly potent next-generation macrolid. the first fluoroketolid. which has potent activity against most macrolide-resistant strains. Solithromycin (CEM-101) is a novel fluoroketolide with improved antimicrobial effectiveness.

應用

Solithromycin has been shown to have potentent activity against S. pneumoniae as well as an extended spectrum of activity against CA-MRS. enterococc according to in vitro and in vivo research. Solithromycin has been used in:

• the research on the anti-inflammatory effects of macrolides
• the research of potency of solithromycin in comparison to other antimicrobials
• in ithe research of the vitro activity of solithromycin against clinical N. gonorrhoeae isolates and reference strain

生化／生理作用

Mode of Action: Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis. Like other ketolide. it should impair bacterial ribosomal subunit formation.

Antimicrobial spectrum: Active against bacteria like Legionella, Chlamydophila, Chlamydia, Mycoplasma, and Ureaplasma and against gonococci and other organisms that cause genitourinary tract infections

特點和優勢

High quality antibiotic suitable for mulitple research applications

其他說明

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安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable