SAB5702866

Anti-Furin Antibody, clone 1P6N8, Rabbit Monoclonal

• 同義詞: FUR, PACE, PCSK3, SPC1
• 分類程式碼代碼: 12352203
• NACRES: NA.46
• 無性繁殖: 1P6N8, monoclonal
• application: IP; WB
• 物種活性: mouse, mouse
• 技術: immunoprecipitation (IP): 1:50 - 1:200; western blot: 1:500 - 1:2000

屬性

• 生物源: rabbit
• 品質等級: 100
• 材料: colorless
• 無性繁殖: 1P6N8, monoclonal
• 形狀: liquid
• 分子量: 90 kDa
• 物種活性: mouse, mouse
• 濃度: 1.20 mg/mL
• 技術: immunoprecipitation (IP): 1:50 - 1:200; western blot: 1:500 - 1:2000
• 顏色: colorless
• 同型: IgG
• 免疫原序列: GEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH
• UniProt登錄號: P09958
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... FURIN(5045)

描述

一般說明

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

免疫原

A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Furin (P09958).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

應用

WB, IP

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1