SAB5702658

Anti-CHM Antibody, clone 2F7W2, Rabbit Monoclonal

• 同義詞: CHM, DXS540, GGTA, HSD-32, REP-1, TCD, CHM, Rab escort protein 1
• 分類程式碼代碼: 12352203
• NACRES: NA.46

屬性

• 生物源: rabbit
• 品質等級: 100
• 材料: colorless
• 無性繁殖: 2F7W2, monoclonal
• 形狀: liquid
• 分子量: 101 kDa
• 物種活性: human
• 濃度: 0.40 mg/mL
• 技術: western blot: 1:500 - 1:2000
• 顏色: colorless
• 同型: IgG
• 免疫原序列: MADTLPSEFDVIVIGTGLPESIIAAACSRSGRRVLHVDSRSYYGGNWASFSFSGLLSWLKEYQENSDIVSDSPVWQDQILENEEAIALSRKDKTIQHVEV
• UniProt登錄號: P24386
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... CHM(1121)

描述

一般說明

This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene.

免疫原

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CHM (P24386).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

應用

WB

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1