SAB5702444

Anti-Rad50 Antibody, clone 5M2K10, Rabbit Monoclonal

• 同義詞: NBSLD, RAD502, hRad50
• 分類程式碼代碼: 12352203
• NACRES: NA.46

屬性

• 生物源: rabbit
• 品質等級: 100
• 材料: colorless
• 無性繁殖: 5M2K10, monoclonal
• 形狀: liquid
• 分子量: 154 kDa
• 物種活性: rat, human, rat
• 濃度: 0.85 mg/mL
• 技術: immunoprecipitation (IP): 1:50 - 1:200; western blot: 1:500 - 1:2000
• 顏色: colorless
• 同型: IgG
• 免疫原序列: RCSAGQKVLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIV
• UniProt登錄號: Q92878
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... RAD50(10111)

描述

一般說明

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010]

免疫原

A synthetic peptide corresponding to a sequence within amino acids 1200-1300 of human Rad50 (Q92878).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

應用

WB,IP

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1