SAB5702320

Anti-MEKK3 Antibody, clone 9N3Y9, Rabbit Monoclonal

• 同義詞: MAPKKK3, MEKK3
• 分類程式碼代碼: 12352203
• NACRES: NA.46
• 無性繁殖: 9N3Y9, monoclonal
• application: WB
• 物種活性: mouse, mouse
• 技術: western blot: 1:500 - 1:2000

屬性

• 生物源: rabbit
• 品質等級: 100
• 材料: colorless
• 無性繁殖: 9N3Y9, monoclonal
• 形狀: liquid
• 分子量: 78 kDa
• 物種活性: mouse, mouse
• 濃度: 1.05 mg/mL
• 技術: western blot: 1:500 - 1:2000
• 顏色: colorless
• 同型: IgG
• 免疫原序列: MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDL
• UniProt登錄號: Q99759
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... MAP3K3(4215)

描述

一般說明

This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

免疫原

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MEKK3 (Q99759).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

應用

WB

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1