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重要文件

SAB5701817

Sigma-Aldrich

Anti-Phospho-PLN-S16/T17 antibody produced in rabbit

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

liquid

物種活性

mouse, human

濃度

0.84 mg/mL

技術

western blot: 1:500-1:2000

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

phosphorylation (pSer16/pThr17)

基因資訊

human ... PLN(5350)

一般說明

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.

免疫原

A synthetic phosphorylated peptide around of human Phospho-PLN-S16/T17.

外觀

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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