SAB5700317

Anti-Phospho-MDM2-S166 antibody produced in rabbit

• 同義詞: ACTFS, HDMX, MDM2, hdm2
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: 11-14; 24-55
• 物種活性: rat, mouse, human
• 濃度: 0.63 mg/ml
• 技術: immunofluorescence: 1:50-1:100; western blot: 1:500-1:1000
• UniProt登錄號: Q00987
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: phosphorylation (pSer166)
• 基因資訊: human ... MDM2(4193)

描述

一般說明

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

免疫原

A synthetic phosphorylated peptide around S166 of human MDM2 (NP_002383.2).

外觀

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

儲存和穩定性

Store at -20℃. Avoid freeze / thaw cycles.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable