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Key Documents

SAB5600038

Sigma-Aldrich

抗-Gamma H2AX (磷酸化-Ser139) 抗体,兔单克隆抗体

recombinant, expressed in HEK 293 cells, clone RM224, purified immunoglobulin

同義詞:

H2AX Ser139 p, Histone H2AX (phospho ser139)

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

重組細胞

expressed in HEK 293 cells

品質等級

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

RM224, monoclonal
recombinant monoclonal

形狀

buffered aqueous glycerol solution

物種活性

human

濃度

~1 mg/mL

技術

ELISA: 0.2- 1  μg/mL
immunoblotting: 0.5-2 μg/mL
immunocytochemistry: 0.5-2 μg/mL

同型

IgG

NCBI登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

phosphorylation (pSer139)

基因資訊

human ... H2AX(3014)

一般說明

Histone H2AX (H2A histone family member X), a histone variant present in almost all eukaryotes, is coded by H2AFX gene. It is mapped to human chromosome 11q23.2–11q23.3.

特異性

This antibody reacts to Histone H2A.X only when phosphorylated at serine 139. No cross reactivity with other phosphorylated histones.

免疫原

Synthetic peptide corresponding to Phospho-Histone H2AX (Ser139)

生化/生理作用

H2AX (H2A histone family member X) helps to maintain genome stability. It plays an important role in localisation and structuring of the repair focus. H2AX also plays an active role in supplying the active repair proteins. γH2AX participates in DSB repair. This protein serves as a signal and target of phosphorylation in the spreading phase.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

Genome Stability and Human Diseases (2010)
Dong Luo et al.
ACS applied materials & interfaces, 14(13), 14916-14927 (2022-03-23)
Combined radiotherapy (RT) and chemotherapy are prescribed to patients with advanced prostate cancer (PCa) to increase their survival; however, radiation-related side effects and systematic toxicity caused by chemotherapeutic drugs are unavoidable. To improve the precision and efficacy of concurrent RT
Gulam Mohmad Rather et al.
Cancers, 13(5) (2021-03-04)
We tested the antitumor effects of a modified E2F peptide substituting D-Arg for L-Arg, conjugated to penetratin (PEP) against solid tumor cell lines and the CCRF-leukemia cell line, alone and in combination with pemetrexed or with cisplatin. For in-vivo studies

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