推薦產品
生物源
mouse
品質等級
共軛
Peridinin-Chlorophyll-Protein Complex
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
S253-32, monoclonal
形狀
buffered aqueous solution
分子量
antigen predicted mol wt >270, ~120 kDa
物種活性
mouse, rat, human
濃度
1 mg/mL
技術
immunocytochemistry: suitable
western blot: suitable
同型
IgG1
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
mouse ... Notch1(18128)
一般說明
The NOTCH1 gene is mapped to human chromosome 9q34.3. In mice, Notch1 is highly expressed in immature neurons of hippocampus. Notch1 is localized to renal epithelial cells and podocytes of metanephros.
免疫原
Fusion protein amino acids 20-216 (extracellular N-terminus, EGF-like domains 1-5) of mouse Notch1
生化/生理作用
The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Notch signaling pathway is involved in the development and progress of cardiovascular diseases. Notch1 function is predominant in developing kidney compared to compared to the mature organ.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
PBS pH7.4, 50% glycerol, 0.09% sodium azide
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 1
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Postnatal dysregulation of Notch signal disrupts dendrite development of adult-born neurons in the hippocampus and contributes to memory impairment.
Scientific Reports, 6, 25780-25780 (2016)
Phospholipase Cγ1 Mediates Intima Formation Through Akt?Notch1 Signaling Independent of the Phospholipase Activity.
Journal of the American Heart Association, 6(7), e005537-e005537 (2017)
Autophagy is involved in mouse kidney development and podocyte differentiation regulated by Notch signalling.
Journal of Cellular and Molecular Medicine, 21(7), 1315-1328 (2017)
Evolutionary significance of intra-genome duplications on human chromosomes.
Gene, 205(1), 19-27 (1997)
Simvastatin enhances bone marrow stromal cell differentiation into endothelial cells via notch signaling pathway
American Journal of Physiology. Cell Physiology, 296(3), C535-C543 (2009)
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