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Merck
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重要文件

SAB5200921

Sigma-Aldrich

Monoclonal Anti-Notch1 - Percp antibody produced in mouse

clone S253-32, purified immunoglobulin

同義詞:

Anti-Motch, Anti-Neurogenic locus notch homolog protein 1, Anti-Neurogenic locus notch protein homolog, Anti-TAN1

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41
共軛:
Peridinin-Chlorophyll-Protein Complex
application:
ICC
WB
無性繁殖:
S253-32, monoclonal
物種活性:
mouse, rat, human
citations:
5
技術:
immunocytochemistry: suitable
western blot: suitable

生物源

mouse

品質等級

共軛

Peridinin-Chlorophyll-Protein Complex

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

S253-32, monoclonal

形狀

buffered aqueous solution

分子量

antigen predicted mol wt >270, ~120 kDa

物種活性

mouse, rat, human

濃度

1 mg/mL

技術

immunocytochemistry: suitable
western blot: suitable

同型

IgG1

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

mouse ... Notch1(18128)

一般說明

The NOTCH1 gene is mapped to human chromosome 9q34.3. In mice, Notch1 is highly expressed in immature neurons of hippocampus. Notch1 is localized to renal epithelial cells and podocytes of metanephros.

免疫原

Fusion protein amino acids 20-216 (extracellular N-terminus, EGF-like domains 1-5) of mouse Notch1

生化/生理作用

The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Notch signaling pathway is involved in the development and progress of cardiovascular diseases. Notch1 function is predominant in developing kidney compared to compared to the mature organ.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

PBS pH7.4, 50% glycerol, 0.09% sodium azide

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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存取文件庫

Postnatal dysregulation of Notch signal disrupts dendrite development of adult-born neurons in the hippocampus and contributes to memory impairment.
Ding X F, et al.
Scientific Reports, 6, 25780-25780 (2016)
Phospholipase Cγ1 Mediates Intima Formation Through Akt?Notch1 Signaling Independent of the Phospholipase Activity.
Jiang D, et al.
Journal of the American Heart Association, 6(7), e005537-e005537 (2017)
Autophagy is involved in mouse kidney development and podocyte differentiation regulated by Notch signalling.
Zhang C, et al.
Journal of Cellular and Molecular Medicine, 21(7), 1315-1328 (2017)
Evolutionary significance of intra-genome duplications on human chromosomes.
Endo T, et al.
Gene, 205(1), 19-27 (1997)
Simvastatin enhances bone marrow stromal cell differentiation into endothelial cells via notch signaling pathway
Xu J, et al.
American Journal of Physiology. Cell Physiology, 296(3), C535-C543 (2009)

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