SAB4702032

Monoclonal Anti-CD120a purified low endotoxin produced in mouse

• 同義詞: FPF, TBP1, TNF R1, TNFR55, TNFRSF1A, p60
• 分類程式碼代碼: 12352203

屬性

• 共軛: unconjugated
• 品質等級: 100
• 抗體產品種類: primary antibodies
• 無性繁殖: H398, monoclonal
• 形狀: buffered aqueous solution
• 物種活性: human
• 濃度: 1 mg/ml
• 技術: FUNC: suitable; flow cytometry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable
• 同型: IgG2a
• UniProt登錄號: P19438
• 儲存溫度: 2-8°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... TNFRSF1A(7132)

描述

一般說明

CD120a / TNF R1, also known as TNFR55 or TNFRSF1A, is a 55 kDa receptor for tumor necrosis factor alpha and it is expressed in most tissues. By binding its trimeric ligand the CD120a protein forms trimers and the conformation change leads to dissociation of the inhibitory factor SODD from its intracellular death domain and in formation of signaling platform. CD120a can mediate apoptosis, and function as a regulator of inflammation. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.

特異性

The mouse monoclonal antibody H398 recognizes the extracellular domain of CD120a, a 55 kDa receptor for tumor necrosis factor. The antibody blocks biological activity of both natural and recombinant human TNF alpha and TNF beta.

免疫原

Recombinant full length human CD120a

外觀

Phosphate buffered saline (PBS), pH 7.4

準備報告

Purified by protein-A affinity chromatography.

儲存和穩定性

Store at 2-8°C. Do not freeze.

其他說明

The antibody solution should be gently mixed before use.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1