SAB4702025

Monoclonal Anti-EGFR PE produced in mouse

• 同義詞: EGF-R, ERBB1, Her1, NISBD2, PIG61
• 分類程式碼代碼: 12352203

屬性

• 共軛: phycoerythrin (R-PE) conjugate
• 品質等級: 100
• 抗體產品種類: primary antibodies
• 無性繁殖: EGFR1, monoclonal
• 形狀: buffered aqueous solution
• 物種活性: horse, ( Human)
• 技術: flow cytometry: suitable
• 同型: IgG2bκ
• UniProt登錄號: P00533
• 儲存溫度: 2-8°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... EGFR(1956)

描述

一般說明

The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.

特異性

The mouse monoclonal antibody EGFR1 reacts with extracellular domain of human protein kinase EGFR (ErbB1 / HER1); epitope within amino acids 6-273.

免疫原

Human epidermoid carcinoma line A431

外觀

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

準備報告

Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

儲存和穩定性

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

其他說明

The antibody solution should be gently mixed before use.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable