SAB4504621

抗-磷酸--MER/SKY (pTyr^749/681) 兔抗

affinity isolated antibody

• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen 110 kDa
• 物種活性: human, rat, mouse
• 濃度: ~1 mg/mL
• 技術: ELISA: 1:10000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI登錄號: Q06418; Q12866
• UniProt登錄號: Q06418
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: phosphorylation (pTyr749/pTyr681)
• 基因資訊: human ... MERTK(10461) , TYRO3(7301)

描述

一般說明

Tyro3 (TYRO3 protein tyrosine kinase) is an 890 amino acid protein that belongs to the TAM (Tyro3, Axl and Mer) receptor family. Tyro3 is mapped to human chromosome 15q15. It is highly expressed in the nervous system like the neocortex, hippocampus and cerebellum. It is also present in monocytes, macrophages, platelets, dendritic cells and NK cells, breast, ovary, testis, lung, kidney, retinal pigment epithelium and osteoclasts.

免疫原

The antiserum was produced against synthesized peptide derived from human MER/SKY around the phosphorylation site of Tyr749/681.

Immunogen Range: 716-765

生化／生理作用

Tyro3 (TYRO3 protein tyrosine kinase) serves as a therapeutic target in breast cancer. This protein is involved in spermatogenesis, immunoregulation, and phagocytosis. It controls disseminated prostate cancer cellular dormancy. TYRO3 helps in the survival and transport of of gonadotropin-releasing hormone (GnRH) neurons within the forebrain. Mutation in TYRO3 result in retinitis pigmentosa.

特點和優勢

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外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable