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Key Documents

SAB4503385

Sigma-Aldrich

Anti-USP30 antibody produced in rabbit

affinity isolated antibody

同義詞:

Deubiquitinating enzyme 30, USP30, Ubiquitin carboxyl-terminal hydrolase 30, Ubiquitin thioesterase 30, Ubiquitin-specific-processing protease 30

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 58 kDa

物種活性

human, rat, mouse

濃度

~1 mg/mL

技術

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... USP30(84749)

一般說明

Anti-USP30 Antibody detects endogenous levels of total USP30 protein.
USP30 (ubiquitin specific peptidase 30) is ubiquitin-specific deubiquitylase. It is located in the mitochondria. It is mapped to human chromosome 12q24.

免疫原

The antiserum was produced against synthesized peptide derived from human USP30.

Immunogen Range: 31-80

應用

Anti-USP30, N-Terminal antibody has been used in western blotting.

生化/生理作用

USP30 controls atypical ubiquitin chains on mitochondria and PARK2 (parkinson juvenile disease protein 2) mediated mitophagy.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

Daily heat stress treatment rescues denervation-activated mitochondrial clearance and atrophy in skeletal muscle
Tamura Y, et al.
The Journal of Physiology, 593(12), 2707-2720 (2015)
USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria
Cunningham CN, et al.
Nature Cell Biology, 17(2), 160-160 (2015)
Deubiquitinating enzymes regulate PARK2-mediated mitophagy
Wang Y, et al.
Autophagy, 11(4), 595-606 (2015)
A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease
Rovelet-Lecrux A, et al.
European Journal of Human Genetics, 20(6), 613-617 (2012)
Ding Yan et al.
Cell death discovery, 7(1), 211-211 (2021-08-13)
Deubiquitinates (DUBs) have been suggested as novel promising targets for cancer therapies. Accumulating experimental evidence suggests that some metal compounds have the potential to induce cancer cell death via inhibition of DUBs. We previously reported that auranofin, a gold(I)-containing agent

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