推薦產品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 56 kDa
物種活性
human, mouse
濃度
~1 mg/mL
技術
ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... GPR101(83550)
一般說明
Anti-GPR101 Antibody detects endogenous levels of total GPR101 protein.
G protein-coupled receptor 101 (GPR101) codes for an an orphan G protein-coupled receptor. It is expressed at high level in the hypothalamus. The GPR101 gene is mapped to human chromosome Xq26.3.
免疫原
The antiserum was produced against synthesized peptide derived from human GPR101.
Immunogen Range: 451-500
Immunogen Range: 451-500
生化／生理作用
Mutation in G protein-coupled receptor 101 (GPR101) gene result in acromegaly. The GPR101 protein is expected to play an important role in hypothalamic control of energy homeostasis. Duplication of the GPR101 gene leads to X-linked acrogigantism (XLAG).
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Gigantism: X-linked acrogigantism and GPR101 mutations.
Iacovazzo D and Korbonits M
Growth Hormone & IGF Research, 30-31, 64-69 (2016)
Germline or somatic GPR101 duplication leads to X-linked acrogigantism: a clinico-pathological and genetic study.
Iacovazzo D, et al.
Acta Neuropathologica Communications, 4(1), 56-56 (2016)
Giampaolo Trivellin et al.
Endocrine-related cancer, 23(5), 357-365 (2016-03-11)
Cushing disease (CD) in children is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. Germline or somatic mutations in genes such as MEN1, CDKIs, AIP, and USP8 have been identified in pediatric CD, but the genetic defects in a significant percentage
Very low frequency of germline GPR101 genetic variation and no biallelic defects with AIP in a large cohort of patients with sporadic pituitary adenomas.
Lecoq AL, et al.
European Journal of Endocrinology, 174(4), 523-530 (2016)
Giampaolo Trivellin et al.
Journal of molecular endocrinology, 57(2), 97-111 (2016-06-11)
We recently showed that Xq26.3 microduplications cause X-linked acrogigantism (X-LAG). X-LAG patients mainly present with growth hormone and prolactin-secreting adenomas and share a minimal duplicated region containing at least four genes. GPR101 was the only gene highly expressed in their
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