SAB4503023

Anti-C1S (heavy chain, Cleaved-Arg⁴³⁷) antibody produced in rabbit

affinity isolated antibody

• 同義詞: C1 esterase, C1S, Complement C1s subcomponent, Complement component 1 subcomponent s
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen 47 kDa; antigen 76 kDa
• 物種活性: human
• 濃度: ~1 mg/mL
• 技術: ELISA: 1:20000; western blot: 1:500-1:1000
• NCBI登錄號: P09871
• UniProt登錄號: P09871
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: proteolytically cleaved (Arg437)
• 基因資訊: human ... C1S(716)

描述

一般說明

Anti-C1S (heavy chain, Cleaved-Arg⁴³⁷ Antibody detects endogenous levels of fragment of activated C1S (heavy chain, Cleaved-Arg⁴³⁷protein.

The C1S (complement C1s) gene is mapped to human chromosome 12p13 and codes for a subcomponent of C1 complex of the classical pathway.

免疫原

The antiserum was produced against synthesized peptide derived from human C1S.

Immunogen Range: 388-437

生化／生理作用

Activation of C1s (complement C1s) along with C1r triggers complement cascade. C1s is responsible for the cleavage of complement component C4 and C2, which is necessary for complete activation of complement system. Studies determined that C1s specifically acts on Val or Leu at P(3) and Ala or Gly residues at P(2) positions. The C1S gene is known to be associated lupus nephritis, with low gene expression observed in mice.

特點和優勢

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外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: nwg
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable