生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 82 kDa
物種活性
mouse, human
濃度
~1 mg/mL
技術
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... PECAM1(5175)
一般說明
抗PECAM-1抗体检测内源性的总PECAM-1蛋白水平。
血小板内皮细胞粘附分子1(PECAM-1)基因长75-kb,位于人类17号染色体长臂上。该基因编码130-kD的一种免疫球蛋白超家族蛋白。这种蛋白是内皮细胞间连接(intercellular junction)的重要成分。PECAM1在循环血小板、单核细胞、中性粒细胞和某些T细胞亚群的表面表达。
免疫原
所制备的抗血清是针对人 PECAM-1 合成的肽。
免疫原范围: 686-735
免疫原范围: 686-735
生化/生理作用
血小板和内皮细胞粘附分子1(PECAM1)也称分化簇31(cluster of differentiation,CD31),它在炎症过程中的粘附级联(adhesion cascade)起关键作用,导致白细胞渗出。PECAM1对于通过血管内皮细胞的细胞间连接而实现的白细胞游出(leukocyte transmigration)至关重要。PECAM1的遗传多态性与动脉粥样硬化事件相关。PECAM1是一种膜糖蛋白,它促进同配和异配粘连。PECAM1 也与血管生成有关。
特點和優勢
请在保持内心完全平静的情况下评估我们的抗体。如果抗体在您的使用中不起作用,我们将全额退款或提供新的抗体。了解更多。
外觀
磷酸盐缓冲盐水中的兔IgG(不含 Mg2+ 和 Ca2+),pH7.4,150mM NaCl,0.02% 叠氮化钠和 50% 甘油。
免責聲明
除非我们的目录或随附于产品的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
nwg
閃點(°F)
Not applicable
閃點(°C)
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。
Biomedical materials (Bristol, England), 12(3), 035004-035004 (2017-06-06)
The development of a new generation of biomaterials with high osteogenic ability for treatment of osteoporotic fractures is being intensively investigated. The objective of this paper was to investigate new bone formation in an ovariectomized rat (OVX rat) calvarial model
Human molecular genetics, 25(23), 5094-5110 (2016-08-16)
Aggf1 is the first gene identified for Klippel-Trenaunay syndrome (KTS), and encodes an angiogenic factor. However, the in vivo roles of Aggf1 are incompletely defined. Here we demonstrate that Aggf1 is essential for both physiological angiogenesis and pathological tumour angiogenesis
Stem cell research & therapy, 12(1), 279-279 (2021-05-12)
We have previously demonstrated that a pooled population of bone marrow-derived, allogeneic mesenchymal stromal cells (BMMSC), Stempeucel®-1, produced under good manufacturing practices (GMP) conditions, showed clinical efficacy and safety in patients suffering from critical limb ischemia (CLI) due to Buerger's
Cell death & disease, 8(5), e2811-e2811 (2017-05-26)
Programmed cell death 5 (PDCD5) is an apoptosis promoter molecule that displays multiple biological activities. However, the function of PDCD5 in vivo has not yet been investigated. Here, we generated a Pdcd5 knockout mouse model to study the physiological role
Investigative ophthalmology & visual science, 61(14), 12-12 (2020-12-15)
Tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie2) activation in Schlemm's canal (SC) endothelium is required for the maintenance of IOP, making the angiopoietin/Tie2 pathway a target for new and potentially disease modifying glaucoma therapies. The goal of the
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