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Merck
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重要文件

SAB4501063

Sigma-Aldrich

Anti-GABBR1 antibody produced in rabbit

affinity isolated antibody

同義詞:

γ-aminobutyric acid type B receptor subunit 1, GABA-B receptor 1, GABA-B-R1, GABBR1, Gb1

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 108 kDa

物種活性

mouse, human, rat

濃度

~1 mg/mL

技術

ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... GABBR1(2550)

相關類別

一般說明

Anti-GABBR1 Antibody detects endogenous levels of total GABBR1 protein.
The γ-aminobutyric acid type B (GABAB) receptor is coded by the GABBR1 gene. It has 22 exons and spans at least 18 kb. GABAB geneis present between an olfactory receptor gene cluster downstream and the HLA (human leukocyte antigen) class I region upstream. It is mapped to human chromosome 6p22.

免疫原

The antiserum was produced against synthesized peptide derived from human GABBR1.

Immunogen Range: 891-940

生化/生理作用

The γ-aminobutyric acid type B (GABAB) is essential for the initiation by agonists like GABA (gamma-aminobutyric acid ). GABAB receptors participates in response habituation. In the visual cortex, GABAB is also involved in the initiation of orientation tuning in conjunction with GABAA receptors.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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存取文件庫

GABBR1 has a HERV-W LTR in its regulatory region?a possible implication for schizophrenia.
Hegyi H.
Biology Direct, 8(1), 5-5 (2013)
Association between Single Nucleotide Polymorphisms in Gamma-Aminobutyric Acid B Receptor, Insulin Receptor Substrate-1, and Hypocretin Neuropeptide Precursor Genes and Susceptibility to Obstructive Sleep Apnea Hypopnea Syndrome in a Chinese Han Population.
Li Z, et al.
Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre, 25(6), 517-524 (2016)
Different roles for GABAA and GABAB receptors in visual processing in the rat superior colliculus.
Binns KE and Salt TE
The Journal of Physiology, 504(3), 629-639 (1997)
GABBR 1 and SLC 6A1, Two Genes Involved in Modulation of GABA Synaptic Transmission, Influence Risk for Alcoholism: Results from Three Ethnically Diverse Populations.
Enoch MA, et al.
Alcoholism, Clinical and Experimental Research, 40(1), 93-101 (2016)

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