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Key Documents

SAB4500961

Sigma-Aldrich

Anti-FLT3 antibody produced in rabbit

affinity isolated antibody

同義詞:

CD135 antigen, STK-1, Stem cell tyrosine kinase 1, Tyrosine-protein kinase receptor FLT3

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 112 kDa

物種活性

mouse, human

濃度

~1 mg/mL

技術

ELISA: 1:1000
western blot: 1:500-1:1000

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... FLT3(2322)

一般說明

Anti-FLT3 antibody detects endogenous levels of total FLT3 protein.
FLT3 (Fms-like tyrosine kinase) is a member of tyrosine kinase (RTK) family. It has an extracellular domain consisting of five immunoglobulin-like domains and an intracellular kinase domain interrupted by a kinase insert. It is located on human chromosome 13q12.

免疫原

The antiserum was produced against synthesized peptide derived from human FLT3.

Immunogen Range: 565-614

生化/生理作用

Mutation in FLT3 (Fms-like tyrosine kinase) results in acute myeloid leukemia and it also induces warburg effect and offers therapeutic sensitivity to glycolytic inhibition.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition
Ju HQ, et al.
Leukemia, 31(10), 2143-2143 (2017)
Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD
Kazi JU, et al.
Cellular and Molecular Life Sciences, 74(14), 2679-2688 (2017)
Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255
Tracy S, et al.
Cancer Research, 64(20), 7241-7244 (2004)

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