推薦產品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 265 kDa
物種活性
human, rat, mouse
濃度
~1 mg/mL
技術
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CREBBP(1387)
一般說明
Anti-CBP Antibody detects endogenous levels of total CBP protein. CREB binding protein (CBP) is a histone acetyltransferase, which is part of the KAT3 family of histone acetyltransferases. The gene encoding it is localized on human chromosome 16p13.3.
免疫原
The antiserum was produced against synthesized peptide derived from human CBP.
Immunogen Range: 1501-1550
Immunogen Range: 1501-1550
生化／生理作用
CREB binding protein (CBP) has a role in the activation of the innate immune response, activation of histones and non-histones through acetylation. It also plays an important role in cAMP-dependent and Wnt signaling. The protein is also involved in modulating the cell cycle, DNA damage repair, ubiquitination and antigen presentation. Mutations in the CBP gene have been associated with Rubinstein-Taybi syndrome. It has also been linked with acute lymphoblastic leukemia.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response.
Dixon ZA
Haematologica (2017)
Mapping the interactions of adenoviral E1A proteins with the p160 nuclear receptor coactivator binding domain of CBP.
Protein Science (2016)
Submicroscopic deletions at 16p13.3 in
Rubinstein-Taybi syndrome: frequency and
clinical manifestations in a North American
population
Rubinstein-Taybi syndrome: frequency and
clinical manifestations in a North American
population
Robert Wallerstein
Journal of medical Genetics (1997)
Jin Ran Chen et al.
The Journal of endocrinology (2018-07-28)
Intrauterine or early postnatal high-fat diet (HFD) have substantial influences on adult offspring health; however, studies of HFD-induced maternal obesity on regulation of adult offspring bone formation are sparse. Here, we investigated the effects of HFD-induced maternal obesity on both
Yujie Liu et al.
Molecular and cellular biology, 34(21), 3993-4007 (2014-08-27)
T-regulatory (Treg) cells are important to immune homeostasis, and Treg cell deficiency or dysfunction leads to autoimmune disease. A histone/protein acetyltransferase (HAT), p300, was recently found to be important for Treg function and stability, but further insights into the mechanisms
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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