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Merck
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重要文件

SAB4300438

Sigma-Aldrich

Anti-ZAP70 (Ab-493) antibody produced in rabbit

affinity isolated antibody

同義詞:

Anti-FLJ17670 antibody produced in rabbit, Anti-FLJ17679 antibody produced in rabbit, Anti-SRK antibody produced in rabbit, Anti-STD antibody produced in rabbit, Anti-zeta-chain (TCR) associated protein kinase 70kDa antibody produced in rabbit

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

~70 kDa

物種活性

rat, mouse, human

濃度

1 mg/mL

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100

同型

IgG

免疫原序列

(S-Y-Y-T-A)

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... ZAP70(7535)

免疫原

Peptide sequence around aa. 491-495 (S-Y-Y-T-A), according to the protein ZAP70.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

標靶描述

ZAP70 is a 70-kD tyrosine phosphoprotein that associates with the zeta chain and undergoes tyrosine phosphorylation following TCR stimulation. The ZAP70 gene is expressed in T- and natural KILLER cells. Protein-Tyrosine Kinases (PTKs) play an integral role in T-cell activation. Stimulation of the T-cell antigen receptor results in tyrosine phosphorylation of a number of cellular substrates. One of these is the TCR-zeta chain, which can mediate the transduction of extracellular stimuli into cellular effector functions.

外觀

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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Magdalena Witkowska et al.
Cytometry. Part B, Clinical cytometry, 86(6), 410-417 (2014-02-12)
Despite significant progress in treatment, chronic lymphocytic leukemia (CLL) still remains an incurable disease. Major advances have been recently made to understand the molecular pathogenesis underlying CLL, but defects in apoptosis are considered to be the most important factors. Although

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