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Merck
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重要文件

SAB4300077

Sigma-Aldrich

Anti-phospho-TP53 (pSer37) antibody produced in rabbit

affinity isolated antibody

同義詞:

Anti-FLJ92943 antibody produced in rabbit, Anti-LFS1 antibody produced in rabbit, Anti-TRP53 antibody produced in rabbit, Anti-p53 antibody produced in rabbit, Anti-tumor protein p53 antibody produced in rabbit

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.43
共軛:
unconjugated
application:
IF
WB
無性繁殖:
polyclonal
物種活性:
human
citations:
1
技術:
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

~53 kDa

物種活性

human

濃度

1 mg/mL

技術

indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

同型

IgG

免疫原序列

(L-P-SP-Q-A)

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

phosphorylation (pSer37)

基因資訊

human ... TP53(7157)

免疫原

Peptide sequence around phosphorylation site of serine 37 (L-P-S(p)-Q-A), according to the protein TP53.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

標靶描述

p53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes

外觀

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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Meaghan D Waltmann et al.
Biochimica et biophysica acta, 1842(9), 1395-1405 (2014-05-21)
Genome-wide association studies have linked LRP8 polymorphisms to premature coronary artery disease and myocardial infarction in humans. However, the mechanisms by which dysfunctions of apolipoprotein E receptor-2 (apoER2), the protein encoded by LRP8 gene, influence atherosclerosis have not been elucidated

文章

p53 regulates gene expression, cell cycle control and functions as a tumor suppressor. Inactivation of p53 is closely tied to cancer development.

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