推薦產品
生物源
mouse
共軛
unconjugated
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
PL231, monoclonal
形狀
buffered aqueous solution
分子量
antigen ~55 kDa
物種活性
monkey, rat, canine, human, mouse
加強驗證
recombinant expression
Learn more about Antibody Enhanced Validation
濃度
~1.0 mg/mL
技術
indirect immunofluorescence: suitable
western blot: 4.0-8.0 μg/mL using extracts of HL-60 cells
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... PLAUR(5329)
一般說明
Plasminogen activator, urokinase receptor (PLAUR) is a well-characterized receptor for matrix-degrading proteases. It is encoded by the gene mapped to human chromosome 19q13.31.
免疫原
peptide corresponding to a sequence at the C-terminus of human PLAUR/uPAR.
應用
Monoclonal Anti-PLAUR/uPAR antibody produced in mouse has been used in Western blotting (WB).
生化／生理作用
Plasminogen activator, urokinase receptor (PLAUR) plays a vital role in tumor cell invasion, angiogenesis and metastasis. It acts as a key regulator of cell-surface plasminogen activator. It is implicated in various normal and pathological processes. Elevated expression of the gene has been observed in various types of cancers, including head and neck squamous cell carcinoma (HNSCC). Thus, it is considered as an potent biomarker for targeted imaging or therapy. Upregulated expression of PLAUR leads to the progression of kidney disease in children.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到適合的產品？
試用我們的產品選擇工具.
儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer.
Harris N L E, et al.
Oncogene, 36(30), 4288-4288 (2017)
John H Rossmeisl et al.
OncoTargets and therapy, 10, 2077-2085 (2017-04-27)
The expression of the urokinase plasminogen activator receptor (uPAR), a glycosylphosphatidylinositol-anchored protein family member, and the activity of its ligand, urokinase-type plasminogen activator (uPA), have been associated with the invasive and metastatic potentials of a variety of human brain tumors
Association of Serum Soluble Urokinase Receptor Levels With Progression of Kidney Disease in Children.
Schaefer F, et al.
JAMA Pediatrics, 171(11), e172914-e172914 (2017)
Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.
Chang H Y, et al.
PLoS Biology, 2(2), 7-7 (2004)
Yue Lang et al.
Cell death & disease, 10(6), 401-401 (2019-05-28)
Urokinase plasminogen activator receptor (uPAR) is upregulated in podocytes of glomerular diseases and crucially mediates podocyte injury through integrin β3 (ITGB3). We previously showed that the miR-30 family maintains podocyte structure and function by inhibiting injurious calcineurin signaling through nuclear
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務