SAB4200344

Anti-SMYD3 antibody, Mouse monoclonal

clone SMYD3-2, purified from hybridoma cell culture

• 同義詞: Anti-KMT3E, Anti-SET and MYND domain containing 3, Anti-ZMYND1, Anti-Zinc finger MYND domain-containing protein 1, Anti-Zinc finger protein, subfamily 3A (MYND domain containing), 1
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: mouse
• 共軛: unconjugated
• 抗體表格: purified from hybridoma cell culture
• 抗體產品種類: primary antibodies
• 無性繁殖: SMYD3-2, monoclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~43 kDa
• 物種活性: rat, mouse, human
• 濃度: ~1.0 mg/mL
• 技術: western blot: 5-10 μg/mL using whole extracts of HeLa cells
• 同型: IgG1
• UniProt登錄號: Q9H7B4
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... SMYD3(64754) ; mouse ... Smyd3(69726) ; rat ... Smyd3(498295)

描述

一般說明

Monoclonal Anti-SMYD3 (mouse IgG1 isotype) is derived from the hybridoma SMYD3-2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a fusion protein corresponding to a fragment of human SMYD3. SMYD3 belongs to the SMYD family of chromatin regulators. It is a histone methyltransferase, that plays a role in transcriptional regulation as a member of an RNA polymerase complex. SMYD3 contains a SET domain, which is critical for the methylation of histone H3 at Lys⁴ and a myeloid, Nervy, and DEAF-1 (MYND)-type zinc-finger domain, which is common to developmental proteins.

免疫原

Fusion protein corresponding to a fragment of human SMYD3.

應用

Monoclonal Anti-SMYD3 antibody produced in mouse has been used in immunoblotting and immunoprecipitation.

生化／生理作用

SMYD3 is important in heart and skeletal muscle development. Overexpression of SMYD3 is observed in hepatocellular cancer, colorectal cancer and breast cancer. SMYD3 is essential for estrogen receptor-regulated gene transcription in the estrogen signaling pathway.

外觀

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable