SAB4200178

Anti-Importin 5 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• 同義詞: Anti-IPO5, Anti-KPNB3, Anti-importin subunit beta-3, Anti-karyopherin beta-3
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 200
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~123 kDa
• 物種活性: human
• 濃度: ~1.0 mg/mL
• 技術: immunoprecipitation (IP): 5-10 μg using lysates of human HEK-293T cells.; indirect immunofluorescence: 2.5-5.0 μg/mL using HEK-293T cells overexpressing human Importin 5.; western blot: 2-4 μg/mL using whole extracts of human Jurkat cells.
• UniProt登錄號: O00410
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... IPO5(3843)

描述

一般說明

Importin 5 (IPO5) is encoded by the gene mapped to human chromosome 13q32.2. The encoded protein belongs to the importin β family. It is primarily expressed in cytoplasm, specifically in the nuclear pore complex.

應用

Anti-Importin 5 (N-terminal) antibody produced in rabbit has been used in western blotting, immunoprecipitation and immunofluorescence.

生化／生理作用

Importin 5 (IPO5) in association with nucleoside triphosphates and the small GTP binding protein Ran, facilitates migration of nuclear localization signal (NLS)-containing cargo from cytoplasm to nucleus. IPO5 also plays a vital role in apolipoprotein A-1 excretion and also helps in transport of lipids from peripheral tissues via reverse cholesterol transport pathway. Additionally, the encoded protein facilitates transport of ribosomal proteins and core histones into the nucleus. Mutation in the gene is associated with the development of schizophrenia.

Importin 5 (also known as IPO5, karyopherin β-3, importin subunit β-3, KPNB3 and RANBP5) has been identified as an importin for histones and proteins L23a, S7, and L5, and also to the PB1 subunit of the influenza A virus RNA-dependent RNA polymerase.

外觀

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable