SAB4200129

Anti-Phospholipase A2 (iPLA2) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

• 同義詞: Anti-CaI-PLA2, Anti-GVI, Anti-INAD1, Anti-IPLA2-VIA, Anti-PARK14, Anti-PLA2, Anti-PLA2G6, Anti-PNPLA9, Anti-Phospholipase A2, group VI (cytosolic, calcium-independent), Anti-iPLA2
• MDL號碼: MFCD00803786
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 200
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: ~85 kDa (and ~95 kDa human iPLA2 and ~95 kDa mouse and rat iPLA2.)
• 物種活性: human, mouse, rat
• 濃度: ~1.5 mg/mL
• 技術: western blot: 1.5-3.0 μg/mL using using extracts of HEK-293T cells overexpressing human iPLA₂, RAW264 cell lysates and rat pancreas extracts (S1 fraction).
• UniProt登錄號: O60733
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... PLA2G6(8398) ; mouse ... pla2g6(53357) ; rat ... pla2g6(360426)

描述

一般說明

Calcium-independent phospholipase A2 (iPLA2) belongs to the group six of phospholipase A2 (PLA2) enzymes. The protein is encoded by the gene mapped to human chromosome 22q13.1. iPLA2 is an intracellular enzyme. It is present both in the cytosol and in membrane fractions. The encoded protein contains 752 amino acids and has a mass of 85kDa. It is characterized with a eight ankyrin repeats and a catalytic domain.

應用

Anti-Phospholipase A2 (iPLA2) antibody produced in rabbit has been used in western blotting.

生化／生理作用

Calcium-independent phospholipase A2 (iPLA2) in the absence of Ca²⁺, catalyzes the hydrolysis of the Sn-2 ester bond in phospholipids to produce free fatty acids and lysophospholipids. iPLA2 might play an essential role in activating the receptor-mediated signaling pathway. Additionally, it also yields precursors for bioactive compounds such as eicosanoid and platelet-activating factor. The encoded protein performs housekeeping role in phospholipid remodeling.

外觀

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable