SAB4200073

Anti-Transglutaminase-2 (C-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

• 同義詞: Anti-C polypeptide, protein-glutamine-gamma-glutamyltransferase, Anti-G-alpha-h, Anti-TG2, Anti-TGC, Anti-TGM2
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~78 kDa
• 物種活性: human
• 包裝: antibody small pack of 25 μL
• 濃度: ~1.5 mg/mL
• 技術: immunohistochemistry: 5-10 μg/mL using formalin-fixed and paraffin embedded human placenta; immunoprecipitation (IP): 15-30 μg using human placenta extracts; indirect immunofluorescence: 2-4 μg/mL using U87 cells; western blot: 1-2 μg/mL using U87 cell extracts
• UniProt登錄號: Q07283
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... TGM2(7052)

描述

一般說明

Tranglutaminase-2 (also known as TGM2, TG2), is a widely expressed, multifunctional protein.

應用

Anti-Transglutaminase-2 (C-terminal) antibody produced in rabbit has been used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence
• immunohistochemistry

生化／生理作用

Tranglutaminase-2 possesses enzymatic and GTPase activities, involved in multiple cell functions, including cell adhesion and cell signaling. TGM2 functions as a Ca²⁺-dependent enzyme capable of crosslinking both cytosolic and extracellular matrix proteins by catalyzing the formation of isopeptide bonds between lysine and glutamine residues. TGM2 is involved in the regulation of cell-matrix adhesion, cytoskeletal structure, cell migration and apoptosis. It is activated in response to tissue injury and plays an important role in wound healing and immune response. TGM2 is a major autoantigen in celiac disease and altered TGM2 expression or activity may be associated with Alzheimer′s disease, arteriosclerosis, type-2 diabetes and cancer metastasis in numerous forms of cancer.

外觀

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable