推薦產品
一般說明
Rift valley fever virus (RVFV) is an enveloped RNA virus belonging to the Phlebovirus genus of the family Bunyaviridae. RVFV possesses a single stranded segmented RNA genome composed of a large (L), a medium (M), and a small (S) segment. The L segment codes for the RNA-dependent RNA polymerase. The M segment codes for a polyprotein which is the precursor to the glycoproteins G1 and G2 and two non-structural proteins, 14K and 78K. The S segment codes for the nucleoprotein N and the non-structural protein NSs.
免疫原
Antibody was raised against a 20 amino acid synthetic peptide near the center of the RVF virus.
生化／生理作用
Rift valley fever virus (RVFV) causes rift valley fever (RVF), an arthropod-borne viral disease. The virus is transmitted either by an arthropod or direct transmission by contact or aerosol among the hosts. The non-structural phosphoprotein (NSs) is responsible for the virulence in the pathogenic RVFV and suppresses human interferon gene expression. The fever is mainly observed in sheep and cattle. In humans, RVF clinical symptoms includes benign fever to severe encephalitis, retinitis, and fatal hepatitis with haemorrhagic fever. RVFV may block α/β interferon (IFN-α/β) expression in host and may target transcription factor aswell TFIIH.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
聯結
The action of this antibody can be blocked using blocking peptide SBP3500929.
外觀
Supplied at 1 mg/mL in PBS with 0.02% sodim azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到適合的產品？
試用我們的產品選擇工具.
儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcription
Billecocq A, et al.
Journal of Virology, 78(18), 9798-9806 (2004)
Mutagen-directed attenuation of Rift Valley fever virus as a method for vaccine development
Caplen H, et al.
The Journal of General Virology, 66, 2271-2277 (1985)
Genetic evidence for an interferon-antagonistic function of rift valley fever virus non-structural protein NSs
Bouloy M, et al.
Journal of Virology, 75(3), 1371-1377 (2001)
C Giorgi et al.
Virology, 180(2), 738-753 (1991-02-01)
The sequences and coding strategies of the S RNAs of two viruses, Toscana (TOS) and the M12 derivative of Rift Valley fever ZH-548 (RVF, Phlebovirus genus, Bunyaviridae) have been determined from cDNA clones and compared to the previously published sequences
Global Trade Item Number
| 庫存單位 | GTIN |
|---|---|
| SAB3500929-100UG | 4061832497471 |
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務