SAB3500302

Anti-LIS1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 同義詞: Anti-Lissencephaly 1, Anti-PAFAH, Anti-Platelet-activating factor acetylhydrolase
• MDL號碼: MFCD03457563
• 分類程式碼代碼: 12352203
• PubChem物質ID: 329824640
• NACRES: NA.43

屬性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 物種活性: human, rat, mouse
• 技術: immunocytochemistry: suitable; immunofluorescence: suitable; indirect ELISA: suitable; western blot: suitable
• NCBI登錄號: P43034
• UniProt登錄號: P43034
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• SMILES 字串: [P](=O)(OCC(O)COC(=O)CCCCCCC\C=C\C\C=C\CCCCC)(O)O
• InChI: 1S/C21H39O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h6-7,9-10,20,22H,2-5,8,11-19H2,1H3,(H2,24,25,26)/b7-6+,10-9+
• InChI 密鑰: ZQTAMPRZFOOEEP-AVQMFFATSA-N
• 基因資訊: human ... PAFAH1B1(5048)

描述

一般說明

The gene PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1) encodes a protein named LIS1 (lissencephaly-1) that forms the α subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase (PAFAH). The gene is mapped to human chromosome 17p13.3.

免疫原

LIS1 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human LIS1.

應用

Monoclonal Anti-LIS1 antibody produced in mouse has been used in immunofluorescence.

生化／生理作用

The heterotrimeric enzyme, platelet-activating factor acteylhydrolase (PAFAH), catalyzes the cleavage of acetyl group at the SN-2 position of platelet-activating factor. The α subunit encoded by the gene PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1) interacts with tubulin and affects microtubule dynamics. Mutations in this gene have been linked to Miller–Dieker lissencephaly, a human brain malformation characterized by a smooth cerebral surface and a disordered organization of the cortical layers resulting from a defect in neuronal migration.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

聯結

The action of this antibody can be blocked using blocking peptide SBP3500302.

外觀

Supplied in PBS with 0.02% sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable