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Key Documents

SAB3500242

Sigma-Aldrich

Anti-DARC antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

同義詞:

Anti-CADM3, Anti-Cell adhesion molecule 3, Anti-Duffy antigen, Anti-Fy glycoprotein, Anti-GpFy

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

物種活性

human, mouse, rat

技術

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... DARC(2532)

一般說明

Duffy antigen/chemokine receptor (DARC) or atypical chemokine receptor 1 (ACKR1) is a membrane-bound protein. The gene encoding this chemokine receptor is localized on human chromosome 1q23.2.

免疫原

DARC antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human DARC.

生化/生理作用

Duffy antigen/chemokine receptor (DARC) or atypical chemokine receptor 1 (ACKR1) functions as an antigen of the Duffy (Fy) blood group system. It has a role in the infection of red blood cells (RBCs) by Plasmodium vivax and the lysis of RBCs by Staphylococcus aureus. The protein has been shown to be downregulated in colorectal cancer.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

聯結

The action of this antibody can be blocked using blocking peptide SBP3500242.

外觀

Supplied in PBS with 0.02% sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

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您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

High-throughput Kell, Kidd, and Duffy matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry?based blood group genotyping of 4000 donors shows close to full concordance with serotyping and detects new alleles
Stefan Meyer
Transfusion (2014)
Population genetic analysis of the DARC locus (Duffy) reveals adaptation from standing variation associated with malaria resistance in humans.
McManus KF
PLoS Genetics (2017)
Expression of Duffy antigen receptor for chemokines (DARC) is down-regulated in colorectal cancer.
Zhou S
Journal of Receptor and Signal Transduction Research (2015)
Staphylococcus aureus Targets the Duffy Antigen Receptor for Chemokines (DARC) to Lyse Erythrocytes.
Spaan AN
Cell host & microbe (2015)

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