SAB3500095

Anti-JMJD2A antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 同義詞: Anti-Jumonji domain-containing protein 2A, Anti-KDM4A, Anti-Lysine-specific demethylase 4A
• 分類程式碼代碼: 12352203

屬性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 物種活性: mouse, rat, human
• 技術: immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• NCBI登錄號: CAH71021
• UniProt登錄號: O75164
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... KDM4A(9682)

描述

免疫原

JMJD2A antibody was raised against a 14 amino acid peptide from near the center of human JMJD2A.

特點和優勢

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標靶描述

Members of the Jumonji domain 2 (JMJD2) family contain a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. The first member of this group, JMJD2A, is widely expressed in human tissues and cell lines and functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. JMJD2A can also form a complex with the androgen receptor (AR), a transcription factor that is pivotal for the development of prostate cancer. Overexpression of JMJD2A stimulates AR function and this stimulation is dependent on JMJD2A catalytic activity, suggesting that JMJD2A might be a critical protein with roles in cell proliferation and oncogenesis.

聯結

The action of this antibody can be blocked using blocking peptide SBP3500095.

外觀

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable