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Key Documents

SAB2702316

Sigma-Aldrich

Monoclonal Anti-CEP152 antibody produced in mouse

clone GT1315, affinity isolated antibody

同義詞:

MCPH4, MCPH9, SCKL5

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

GT1315, monoclonal

形狀

buffered aqueous solution

分子量

189kDa

物種活性

human

濃度

1mg/mL

技術

western blot: 1:500-1:3000

同型

IgG1

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... CEP152(22995)

相關類別

一般說明

CEP152 (centrosomal protein 152), a mammalian ortholog of Drosphila asterless is a component of mammalian centrosomes. It is located on human chromosome 15.

免疫原

Recombinant protein encompassing a sequence within the N-terminus region of human CEP152.

應用

Suggested starting dilutions are as follows: WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

生化/生理作用

This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq]
CEP152 (centrosomal protein 152) plays an important role in cell division and development. It is highly essential for the recruitment of centriole of Plk4 (polo-like kinase 4) and centriole duplication at the time of cell cycle.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

其他說明

Purification: Affinity purified by Protein G

外觀

Phosphate-buffered saline, no preservative added.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication.
Sonnen KF, et al.
Journal of Cell Science, 126(14), 3223-3233 (2013)
Primary autosomal recessive microcephaly: homozygosity mapping of MCPH4 to chromosome 15.
Jamieson CR, et al.
American Journal of Human Genetics, 65(5), 1465?1469-1465?1469 (1999)
Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4.
Guernsey DL, et al.
American Journal of Human Genetics, 87(1), 40-51 (2010)

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