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Key Documents

SAB2501472

Sigma-Aldrich

Anti-SLC2A4 (C-terminal) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

同義詞:

Anti-GLUT4, Glucose transporter 4, Insulin-responsive glucose transporter type 4, Solute carrier family 2 (facilitated glucose transporter), member 4

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

goat

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

物種活性

rat, mouse, human, bovine

技術

ELISA: suitable
immunohistochemistry: suitable
western blot: suitable

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... SLC2A4(6517)

一般說明

Solute carrier family 2 member 4 (SLC2A4) is also known as glucose transporter-4 (GLUT4). It is highly expressed in adipose tissue and skeletal muscles. The gene encoding SLC2A4 is localized on human chromosome 17p13.

免疫原

Peptide with sequence TELEYLGPDEND, from the C-terminal region of the protein sequence according to NP_001033.1

生化/生理作用

Solute carrier family 2 member 4 (SLC2A4) transports glucose into cells in response to insulin. Levels of this protein have been shown to be reduced in type 2 diabetes.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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G I Bell et al.
Diabetes, 38(8), 1072-1075 (1989-08-01)
Glucose uptake by heart, skeletal muscle, and adipose tissue is acutely regulated by insulin, which stimulates facilitative glucose transport, at least in part, by promoting the translocation of transporters from an intracellular pool to the plasma membrane. cDNAs encoding the
Malgorzata Malodobra-Mazur et al.
Gene, 576(1 Pt 3), 499-504 (2015-11-04)
The glucose uptake by numerous cells like adipocytes or skeletal muscle cells requires activation of specific proteins called glucose transporters. GLUT4 content and its activation as well as SLC2A4 gene expression level are decreased in patients with type 2 diabetes.
Wei-Feng Shan et al.
Journal of Zhejiang University. Science. B, 12(8), 677-682 (2011-07-29)
Decreased glucose tolerance and diabetes are frequently observed in advanced liver cirrhosis patients and may be related to insulin resistance. Glucose transporter-4 (GLUT4), one of the most important glucose transporters, plays a key role in the development of type 2

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