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Merck
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重要文件

SAB2500080

Sigma-Aldrich

Anti-APOB antibody produced in goat

affinity isolated antibody, buffered aqueous solution

同義詞:

Anti-ApoB-100, Anti-ApoB-48, Anti-Apolipoprotein B (including Ag(x) antigen), Anti-FLDB

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

goat

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

物種活性

human

技術

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... APOB(338)

一般說明

Apolipoprotein B (APOB), a large amphipathic glycoprotein, has hydrophobic lipid-binding and hydrophilic regions. It has a low-density lipoprotein (LDL)-receptor-binding domain. The APOB gene with 29 exons produces two forms, such as apoB-48 and apoB-100 in circulating lipoproteins. This gene is located on human chromosome 2p24.1.

免疫原

Peptide with sequence C-TDLHLRYQKDKK from the internal region of the protein sequence according to NP_000375.2.

應用

Anti-APOB antibody produced in goat has been used in enzyme-linked immunosorbent assay (ELISA).

生化/生理作用

Apolipoprotein B (APOB) participates in human lipoprotein metabolism. APOB-48 plays an essential role in the synthesis of chylomicron. APOB-100 is required for the structural component of very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and low-density lipoprotein (LDL). APOB is essential in the molecular diagnosis of familial hypercholesterolemia (FH). The hydrophobic lipid-binding and hydrophilic regions are capable of interacting with the aqueous plasma environment.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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存取文件庫

Guiting Zhang et al.
Molecular medicine reports, 23(2) (2020-12-24)
Patients with antiphospholipid syndrome have been identified to have higher incidence rates of atherosclerosis (AS) due to the elevated levels of anti‑β2‑glycoprotein I (β2GPI) antibody (Ab). Our previous studies revealed that the anti‑β2GPI Ab formed a stable oxidized low‑density lipoprotein (oxLDL)/β2GPI/anti‑β2GPI Ab complex

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