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Merck
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Key Documents

SAB1408054

Sigma-Aldrich

Anti-RNF146 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

同義詞:

DKFZp434O1427, RP3-351K20.1, dJ351K20.1

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

品質等級

共軛

unconjugated

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen ~38.8 kDa

物種活性

human

技術

western blot: 1 μg/mL

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... RNF146(81847)

免疫原

RNF146 (NP_112225.2, 1 a.a. ~ 358 a.a) full-length human protein.

Sequence
MAGCGEIDHSINMLPTNRKANESCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDANTVNLARESSADGADSVSAQSGASVQPLVSSVRPLTSVDGQLTSPATPSPDASTSLEDSFAHLQLSGDNTAERSHRGEGEEDHESPSSGRVPAPDTSIEETESDASSDSEDVSAVVAQHSLTQQRLLVSNANQTVPDRSDRSGTDRSVAGGGTVSVSVRSRRPDGQCTVTEV

外觀

Solution in phosphate buffered saline, pH 7.4

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.
DaRosa PA
Nature, 517, 223-223 (2015)
RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146.
Matsumoto Y, et. al.
The Journal of Clinical Investigation, 127, 1303-1303 (2017)
Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism.
Matsumoto Y, et. al.
The Journal of Clinical Investigation, 127, 2612-2612 (2017)
Overexpression of RNF146 in non-small cell lung cancer enhances proliferation and invasion of tumors through the Wnt/?-catenin signaling pathway.
Gao Y
PLoS ONE, 9, e85377-e85377 (2014)
Yoshinori Matsumoto et al.
The Journal of clinical investigation, 127(7), 2612-2625 (2017-06-06)
Cleidocranial dysplasia (CCD) is an autosomal dominant human disorder characterized by abnormal bone development that is mainly due to defective intramembranous bone formation by osteoblasts. Here, we describe a mouse strain lacking the E3 ubiquitin ligase RNF146 that shows phenotypic

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