SAB1401365

Anti-SLC14A1 antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

• 同義詞: FLJ33745, FLJ41687, HUT11, HsT1341, JK, RACH1
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 物種活性: mouse, human
• 技術: western blot: 1 μg/mL
• NCBI登錄號: BC050539
• UniProt登錄號: Q13336
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... SLC14A1(6563)

描述

一般說明

The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene forms the basis for the Kidd blood group system. (provided by RefSeq)

免疫原

SLC14A1 (AAH50539.1, 1 a.a. ~ 389 a.a) full-length human protein.

Sequence
MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSVLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFENIYFGLWGFNSSLACIAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIYKMPLSKVTYPEENRIFYLQAKKRMVESPL

生化／生理作用

SLC14A1 (solute carrier family 14 member 1) mediates the transport of urea across cell membrane and maintains its concentration in bladder urothelial cells. Variation or mutation in SLC14A1 is associated with the risk of bladder cancer and also with hypertension and metabolic syndrome. Thus, the gene serves as an important prognostic marker in the detection of urothelial carcinoma. SLC14A1 knockout promotes DNA damage and cell death in bladder urothelium. In human, silencing SLC14A1 gene accounts for Kidd blood type and therefore, the gene plays a role in transfusion medicine and organ transplantation.

外觀

Solution in phosphate buffered saline, pH 7.4

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable