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一般說明
Retinoschisin 1 (RS1) is a localized in the retina and pineal. Its is encoded by the X-linked retinoschisis (XLRS) gene and is 24 kDa. It consists of a signal sequence, RS1 domain, discoidin domain and a C-terminal domain. It is secreted by the retinal neurons as a homo-octameric complex.
免疫原
synthetic peptide corresponding to amino acids 66-78 of human RS1
應用
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
生化／生理作用
Retinoschisin 1 (RS1) plays a role in binding of β-2-laminin, αβ-crystallin, phospholipid, galactose and Na/K ATPase−SARM1 (Sterile alpha and TIR motif-containing protein 1) complex. Mutations in the RS1 gene leads to a condition called as X-linked juvenile retinoschisis which leads to macular degradation in males and deterioration of vision.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Inactivation of the murine X-linked juvenile retinoschisis gene, Rs1h, suggests a role of retinoschisin in retinal cell layer organization and synaptic structure
Weber B H F, et al.
Proceedings of the National Academy of Sciences of the USA, 99(9), 6222-6227 (2002)
Intravitreal delivery of AAV8 retinoschisin results in cell type-specific gene expression and retinal rescue in the Rs1-KO mouse
Park T K, et al.
Gene Therapy, 16(7), 916-916 (2009)
Molecular pathology of X linked retinoschisis: mutations interfere with retinoschisin secretion and oligomerisation
Wang T, et al.
The British Journal of Ophthalmology, 90(1), 81-86 (2006)
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