推薦產品
生物源
rabbit
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~37 kDa
物種活性
human
技術
western blot: 1:500-1:2,000
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... LDHA(3939)
一般說明
Lactate dehydrogenase A (LDHA) or the M subunit is a cytosolic enzyme and is abundantly present in the skeletal muscle. Lactate dehydrogenase B (LDHB) or the H subunit is mainly seen in the heart. Both genes are capable of forming homotetramers or heterotetramers. LDHA gene is located on human chromosome 11p15.4.
免疫原
synthetic peptide corresponding to amino acids 216-228 of human LDHA
應用
Anti-LDHA (216-228) antibody produced in rabbit has been used in:
- in situ
- proximity ligation assay (PLA)
- immuno-staining
- western blotting
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
生化／生理作用
Lactate dehydrogenase A (LDHA) participates in anaerobic and aerobic glycolysis. It can regenerate nicotinamide adenine dinucleotide (NAD+) from NADH to maintain the ATP synthesis in the absence of adequate oxygen. The N-terminus of LDHA is essential for the stability of the structure.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Rosemarie Krupar et al.
Virchows Archiv : an international journal of pathology, 465(3), 299-312 (2014-07-17)
An HPV infection is involved in the etiology of about 25 % of head and neck squamous cell carcinomas (HNSCC). It has been postulated that a strong antitumoral immune response in HPV-positive tumors represents an important underlying mechanism for their
文章
We presents an article about the Warburg effect, and how it is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer cells show an increased dependence on glycolysis to meet their energy needs, regardless of whether they were well-oxygenated or not.
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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